Nuclear Cardiology

General Information

P.O. Box 208042
New Haven, CT 06520-8042
Admin Assistant: Roberta O'Brien

Yale Nuclear Cardiology laboratories are located both at Yale-New Haven Hospital and the Veterans Administration Medical Center. The staff includes 6 full time faculty in Nuclear Cardiology, 2 senior fellows in Nuclear Cardiology, and a team of nuclear medicine technologists, nurses and exercise physiologists. Nuclear Cardiology has representation from both Diagnostic Radiology (1.5 FTE) and the Section of Cardiovascular Medicine from the Department of Internal Medicine (4.5 FTE).

Laboratories and Centers

The Cardiovascular Nuclear Imaging and Exercise Laboratories at Yale comprise a comprehensive exercise and imaging center that is fully accredited by the Intersocietal Commission for Accreditation of Nuclear laboratories (ICANL). The laboratory performs cardiac perfusion and function studies, utilizing state-of-the-art tomographic and planar imaging equipment. Both Thallium and Technetium-labeled tracers are used daily in conjunction with physical and pharmacological stress testing, Static and ECG-gated tomographic and planar images are interpreted both visually and with commercially available quantitative software developed and validated in our laboratory.

In addition, the laboratory provides Yale-New Haven Hospital Emergency Department Chest Pain Center with complete stress testing capabilities including SPECT imaging. The laboratory is fully digital and networked. All imaging studies are digitally archived. The laboratory has unique logistics in place for remote internet reading of clinical studies through a dedicated Yale Nuclear Cardiology Laboratory web site.

The laboratories at Yale and the VA perform over 7,000 clinically requested studies in outpatients and in-patients. Most studies are performed in conjunction with either physical or pharmacological stress testing. The laboratory performs the following stress modalities: physical treadmill/bicycle exercise, pharmacologic vasodilation with either dipyridamole or adenosine, pharmacologic stress with dobutamine, exercise cardiopulmonary testing. Most stress tests are performed with radionuclide imaging, but stress echocardiography is also available. Left and right ventricular function studies are mostly performed at rest using the first pass or equilibrium technique. An important clinical service is provided in the Chest Pain Center. On an average 4-5 patients/day are evaluated for acute chest pain by either resting imaging or stress testing.

Clinical Trails

The Yale laboratory has served as the Core Laboratory for many multicenter clinical trials, including the TIMI trials, the recently completed Acute Chest Pain Tetrofosmin Trial, and the ongoing Detection of Ischemia in Asymptomatic Diabetics (DIAD) trial, for which Dr. Wackers is the principal investigator. The VA laboratory is also active in clinical research projects. In addition, research laboratories dedicated to molecular imaging are located on the VA campus.

Research Direction

  • Advanced cardiovascular and molecular imaging
  • Cardiac metabolism in the setting of ischemia
  • Computer Quantification
  • Heart Disease
  • Myocardial Perfusion
  • Radionuclide Imaging
  • Ventricular Function
  • Diabetes 


Recent Publications:

Books & Chapters

  • Russell RR, Abbott BG, Arrighi JA, Blankstein R, Cohen MC, Faber TL, Mieres JH, Miller TD, Tilkemeier PL, Travin MI, Bax JJ. Highlights of the 2009 Scientific Session of the American Society of Nuclear Cardiology: Minneapolis, Minnesota, October 1-4, 2009. J Nucl Cardiol 17:97-105, 2010. 
  • Russell R, Arrighi JA, Liu Y-H. Nuclear cardiac imaging. In: Cardiovascular Imaging (Y-H Liu and FJTh Wackers eds.), London, Manson Publishing, p. 44-79, 2010. 
  • Russell R. Principles of myocardial metabolism as they relate to imaging. In: Clinical Nuclear Cardiology, 4th edition (B Zaret and GA Beller eds.), Philadelphia, Elsevier, p. 14-26, 2010. 
  • Russell R, Wackers FJTh. CAD detection: Exercise stress SPECT. In: Clinical Nuclear Cardiology, 4th edition (B Zaret and GA Beller eds.), Philadelphia, Elsevier, p. 225-243, 2010. 
  • Miller EJ, Russell RR. Physics and Instrumentation of Cardiac SPECT. In: Imaging of the Cardiovascular System (V Ho and G Reddy), Philadelphia, Elsevier, (in press)
  • Russell R, Taegtmeyer H. Anaplerosis. In: Encyclopedia of Biological Chemistry (W Lennarz and MD Lane ed.), New York: Academic Press, (In Press).

Other Publications:

  • Kalinowoski A, Plowes NJR, Huang Q, Berdejo-Izquierdo C, Russell RR, Russell KS. Metalloproteinase-dependent cleavage of neuregulin and autocrine stimulation of vascular endothelial cells. FASEB J 24: 2567-2575, 2010. 
  • Wu Y, Xu J, Velazquez H, Wang P, Li G, Liu D, Sampaio-Maia B, Quelhas-Santos J, Russell K, Russell R, Flavell RA, Pestana M, Giordano F, Desir GV. 2010. Renalase deficiency aggravates ischemic myocardial damage. Kidney Int doi 10.1038/ki.2010.488, 2010. 
  • Bugger H, Guzman C, Zechner C, Palmeri M, Russell KS, Russell RR. Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation. Cancer Chemother Pharmacol doi 10.1007/s00280-010-1441-7, 2010. 
  • Volkova M, Palmeri M, Russell KS, Russell RR. Activation of the aryl hydrocarbon receptor by doxorubicin mediates cytoprotective effects in the heart. Cardiovascular Research doi 10.1093/cvr/cvr007 in press, 2011. 
  • Qian X, Brennan MP, Dione DP, Dobrucki WL, Jackowski MP, Breuer CK, Sinusas AJ, Papademetris X. A Non-Parametric Vessel Detection Method for Complex Vascular Structures. Medical Image Analysis, 13(1):49-61, 2009. 
  • Brennan MP, Sinusas AJ, Horvath TL, Collins JG, Harding MJ. Correlation Between Body Weight Changes and Postoperative Pain in Rats Treated With Meloxicam or Buprenorphine. Lab. Anim. (NY). 38(3):87-93, 2009. 
  • Dobrucki LW, Dione DP, Kalinowski L, Dione D, Mendizabal M, Yu J, Papademetris X, Sessa WC, Sinusas AJ. Serial noninvasive targeted imaging of peripheral angiogenesis: Validation and application of a semiautomated quantitative approach. J Nucl Med 50:1356-1363, 2009. 
  • Mekkaoui C,  Jadbabaie J, Dione DP, Meoli DF, Purushothaman K, Belardinelli L, Sinusas AJ. Effects of Adenosine and a Selective A2A Adenosine Receptor Agonist on Hemodynamic and 201Tl and 99mTc-SestaMIBI Biodistribution and Kinetics. JACC Cardiovasc Imaging 2:1198-208, 2009. 
  • Zhu Y, Papademetris X, Sinusas AJ, Duncan JS. A Dynamical Shape Prior for LV Segmentation from RT3D Echocardiography. Med Image Comput Comput Assist Interv. 2009;5761:206-213. 
  • Dobrucki LW, Tsutsumi Y, Kalinowski L, Dean J, Gavin M, Sen S, Mendizabal M, Sinusas AJ, Aikawa R. Analysis of angiogenesis induced by local IGF-1 expression after myocardial infarction using microSPECT-CT imaging. J Mol Cell Cardiol. 48(6):1071-9, 2009.
  • Dobrucki LW, Meoli DF, Hu J, Sadeghi MM, Sinusas AJ. Regional Hypoxia Correlates with the Uptake of a Radiolabeled Targeted Marker of Angiogenesis in Rat Model of Myocardial Hypertrophy and Ischemic Injury. J Physiol & Pharm 60(Suppl 4):117-123, 2009. 
  • Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM. Molecular imaging of matrix metalloproteinase activation to predict murine aneurysm expansion in vivo. J Nucl Med. 51(7):1107-15, 2010 PMID: 20554725. 
  • Zhu Y, Papademetris X, Sinusas AJ, Duncan JS. A coupled deformable model for tracking myocardial borders from real-time echocardiography using an incompressibility constraint. Med Image Anal. 14(3):429-48. 2010 PMID: 20350833. 
  • Spinale FG, Mukherjee R, Zavadzkas JA, Koval CN, Bouges S, Stroud RE, Dobrucki LW, Sinusas AJ. Cardiac restricted overexpression of  membrane type-1 matrix metalloproteinases causes adverse myocardial remodeling following myocardial infarction. J Biol Chem 285:30316-27, 2010 PMID: 20643648. 
  • Pearlman PC, Tagare HD, Sinusas AJ, Duncan JS. 3D radio frequency ultrasound cardiac segmentation using a linear predictor. Med Image Comput Comput Assist Interv. 2010;13(Pt 1):502-9. PMID: 20879268.
  • Suh JW, Scheinost D, Dione DP, Dobrucki LW, Sinusas AJ, Papademetris X. A non-rigid registration method for serial lower extremity hybrid SPECT/CT imaging. Med Image Anal 15:96-111, 2011 PMID: 20869902. 
  • Tavakoli S, Razavian M, Zhang J, Nie L, Marfatia R, Dobrucki LW, Sinusas AJ, Robinson S, Edwards DS, Sadeghi MM. Matrix metalloproteinase activation predicts amelioration of remodeling after dietary modification in injured arteries. Arterioscler Thromb Vasc Biol. 31(1):102-9, 2011 PMID: 20947820. 
  • Liu YH, Sahul Z, Weyman CA, Dione DP, Dobrucki WL, Mekkaoui C, Brennan MP, Ryder WJ, Sinusas AJ. Accuracy and Reproducibility of Absolute Quantification of Myocardial Focal Tracer Uptake from Molecularly Targeted SPECT/CT: A Canine Validation. J Nucl Med. 52(3):453-60, 2011 PMID: 21321271