Nuclear Cardiology

General Information


Clinical
Contact
YNHH
Phone: 203-688-4749

Fax: 203-688-3658
Research
Contact
Yale Translational Imaging Center
Phone: 203-785-5005

Yale Nuclear Cardiology laboratories are located at Yale-New Haven Hospital. The staff includes 6 full time clinical faculty in Nuclear Cardiology, computer scientist and medical physicist, senior fellows in Nuclear Cardiology, and a team of nuclear medicine technologists, physician assistants, nurses and exercise physiologists. Nuclear Cardiology has representation from the Section of Cardiovascular Medicine in the Department of Internal Medicine and the Department of Radiology and Biomedical Imaging and  Imaging Sciences.

Laboratories and Centers

The Cardiovascular Nuclear Imaging and Exercise Laboratories at Yale comprise a comprehensive exercise and imaging center that is fully accredited by the Intersocietal Commission for Accreditation of Nuclear laboratories (ICANL) for SPECT/CT, PET/CT and equilibrium blood pool imaging. The laboratory performs cardiac perfusion and function studies, utilizing state-of-the-art SPECT and PET, and planar imaging equipment. Both Thallium-201 and Technetium-99m labeled SPECT tracers and Rubidium-82 and 18F-deoxyglucose (FDG) PET imaging agents are used daily in conjunction with physical and pharmacological stress testing for detection and risk stratification of patients with suspected ischemic heart disease and heart failure.

The laboratory offers many new services including; evaluation of cardiac sarcoidosis and amyloidosis, peripheral arterial disease, microvascular disease, chemotherapy-induced cardiotoxicity, and sympathetic imaging of the heart for risk stratification of patients with heart failure. Static and ECG-gated tomographic and planar images are interpreted both visually and with commercially available quantitative software developed and validated in our laboratory. We routinely provide analysis of quantitative myocardial flow and flow reserve with dynamic Rubidium-82 PET imaging.


In addition, the laboratory provides Yale-New Haven Hospital Emergency Department Chest Pain Center with complete stress testing capabilities including SPECT imaging. The laboratory is fully digital and networked. All imaging studies are digitally archived. The laboratory has unique logistics in place for remote internet reading of clinical studies through a dedicated Yale Nuclear Cardiology Laboratory web site.


The laboratory at Yale perform over 7,000 clinically requested studies in outpatients and in-patients. Most studies are performed in conjunction with either physical or pharmacological stress testing. The laboratory performs the following stress modalities: physical treadmill/bicycle exercise, pharmacologic vasodilation with either regadenoson or adenosine, pharmacologic stress with dobutamine, and exercise cardiopulmonary testing.


Clinical Trails

The Yale laboratory has served as the Core Laboratory for many multi-center clinical trials. The VA laboratory is also active in clinical research projects. In addition, research laboratories dedicated to multi-modality and molecular imaging are located within the Yale Translational Research Imaging Center and on the VA campus.

Research Direction

  • Advanced cardiovascular and molecular imaging
  • Cardiac metabolism in the setting of ischemia
  • Computer Quantification
  • Heart Disease
  • Myocardial Perfusion
  • Radionuclide Imaging
  • Ventricular Function
  • Diabetes 


Recent Publications

Stacy MR, Qiu M, Papademetris X, Caracciolo CM, Constable RT, Sinusas AJ: Application of BOLD Magnetic Resonance Imaging for Evaluating Regional Volumetric Foot Tissue Oxygenation: A Feasibility Study in Healthy Volunteers. Eur J Vasc Endovasc Surg. 2016 May; 2016 Mar 9. PMID: 26970710

McElhinney DB, Cabalka AK, Aboulhosn JA, Eicken A, Boudjemline Y, Schubert S, Himbert D, Asnes JD, Salizzoni S, Bocks ML, Cheatham JP, Momenah TS, Kim DW, Schranz D, Meadows J, Thomson JD, Goldstein BH, Crittendon I 3rd, Fagan TE, Webb JG, Horlick E, Delaney JW, Jones TK, Shahanavaz S, Moretti C, Hainstock MR, Kenny DP, Berger F, Rihal CS, Dvir D, Valve-in-Valve International Database (VIVID) Registry: Transcatheter Tricuspid Valve-in-Valve Implantation for the Treatment of Dysfunctional Surgical Bioprosthetic Valves: An International, Multicenter Registry Study. Circulation. 2016 Apr 19; 2016 Mar 18. PMID: 26994123

Wu J, Lin SF, Gallezot JD, Chan C, Prasad R, Thorn S, Stacy MR, Huang H, Zonouz TH, Liu YH, Lampert RJ, Carson RE, Sinusas AJ, Liu C: Quantitative analysis of dynamic 123I-mIBG SPECT imaging data in healthy humans with a population-based metabolite correction method. J Nucl Med. 2016 Apr 14; 2016 Apr 14. PMID: 27081169

Thorn SL, Sinusas AJ: Editorial in response to: PET/CT evaluation of 18F-FDG uptake in pericoronary adipose tissue in patients with stable coronary artery disease: Independent predictor of atherosclerotic lesion formation? : Is there prognostic value in evaluation of 18F-FDG uptake in the pericoronary adipose tissue? J Nucl Cardiol. 2016 Mar 14; 2016 Mar 14. PMID: 26976143

Yu Y, Chan C, Ma T, Liu Y, Gallezot JD, Naganawa M, Kelada OJ, Germino M, Sinusas AJ, Carson RE, Liu C: Event-by-Event Continuous Respiratory Motion Correction for Dynamic PET Imaging. J Nucl Med. 2016 Feb 23; 2016 Feb 23. PMID: 26912437

Bailey G, Upadhyaya K, Meadows J, Malm B: Eosinophilic Myocarditis Presenting as ST-segment Elevation Myocardial Infarction Diagnosed with Cardiac Magnetic Resonance Imaging. Am J Med. 2016 Feb; 2015 Oct 22. PMID: 26475258

Stacy MR, Sinusas AJ: Novel Applications of Radionuclide Imaging in Peripheral Vascular Disease. Cardiol Clin. 2016 Feb; 2015 Oct 17. PMID: 26590787

Toczek J, Meadows JL, Sadeghi MM: Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification. Circ Cardiovasc Imaging. 2016 Jan. PMID: 26763279

Chan C, Dey J, Grobshtein Y, Wu J, Liu YH, Lampert R, Sinusas AJ, Liu C: The impact of system matrix dimension on small FOV SPECT reconstruction with truncated projections. Med Phys. 2016 Jan. PMID: 26745914

Fan P, Hutton BF, Holstensson M, Ljungberg M, Pretorius PH, Prasad R, Ma T, Liu Y, Wang S, Thorn SL, Stacy MR, Sinusas AJ, Liu C: Scatter and crosstalk corrections for (99m)Tc/(123)I dual-radionuclide imaging using a CZT SPECT system with pinhole collimators. Med Phys. 2015 Dec. PMID: 26632046

Albright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT: ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Nat Commun. 2015 Dec 1; 2015 Dec 1. PMID: 26624227

Stendahl JC, Sinusas AJ: Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 2: Radiolabeled Probes. J Nucl Med. 2015 Nov; 2015 Aug 20. PMID: 26294304

Stendahl JC, Sinusas AJ: Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and Features. J Nucl Med. 2015 Oct; 2015 Aug 13. PMID: 26272808

Liu H, Chan C, Grobshtein Y, Ma T, Liu Y, Wang S, Stacy MR, Sinusas AJ, Liu C: Anatomical-based partial volume correction for low-dose dedicated cardiac SPECT/CT. Phys Med Biol. 2015 Sep 7; 2015 Aug 21. PMID: 26296043

Stacy MR, Zhou W, Sinusas AJ: Radiotracer Imaging of Peripheral Vascular Disease. J Nucl Med Technol. 2015 Sep. PMID: 26338845

Thorn S, Sinusas AJ: Creation of clinically relevant model of chronic heart failure: Application of multi-modality imaging to define physiology. J Nucl Cardiol. 2015 Aug; 2015 Feb 20. PMID: 25698482

Werner RA, Maya Y, Yamane T, Rischpler C, Fukushima K, Chen X, Lapa C, Herrmann K, Higuchi T, Thorn S, Stacy MR, Purcell BP, Doviak H, Shuman JA, Perez E, Burdick JA, Spinale FG, Sinusas AJ, Treibel T, Bandula S, Fontana M, White SK, Gilbertson JA, Punwani SA, Gillmore JD, Hawkins PN, Taylor SA, Moon JC, Caobelli F, Wollenweber T, Kuehn C, Bavendiek U, Schuetze C, Geworski L, Bauersachs J, Haverich A, Bengel FM, Barysheva N, Merkulova IN, Shabanova MS, Gaman SA, Veselova TN, Shariya MA, Kelion AD, Pakkal M, Chowdhury F, Nagaraj N, Birchall J, Dixon K, Banya W, Mccann G, Gershlick A, Rischpler C, Dirschinger RJ, Nicolosi S, Kossmann H, Meinicke A, Hanus F, Goetze K, Laugwitz KL, Schwaiger M, Nekolla SG, Rischpler C, Dirschinger RJ, Nicolosi S, Kossmann H, Meinicke A, Hanus F, Goetze K, Laugwitz KL, Schwaiger M, Nekolla SG: Moderated Poster Session 4: Monday 4 May 2015, 15:30-16:30Room: Moderated Poster Area. Eur Heart J Cardiovasc Imaging. 2015 May. PMID: 25939927

Stacy MR, Paeng JC, Sinusas AJ: The role of molecular imaging in the evaluation of myocardial and peripheral angiogenesis. Ann Nucl Med. 2015 Apr; 2015 Mar 8. PMID: 25750124

Sinusas AJ: Does a shortened hyperemia with regadenoson stress pose a concern for quantitative Rb-82 PET imaging? Optimization of regadenoson PET imaging. JACC Cardiovasc Imaging. 2015 Apr. PMID: 25882574

Cantley JL, Vatner DF, Galbo T, Madiraju A, Petersen M, Perry RJ, Kumashiro N, Guebre-Egziabher F, Gattu AK, Stacy MR, Dione DP, Sinusas AJ, Ragolia L, Hall CE, Manchem VP, Bhanot S, Bogan JS, Samuel VT: Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats. Am J Physiol Endocrinol Metab. 2014 Nov 1; 2014 Aug 26. PMID: 25159329

Stacy MR, Naito Y, Maxfield MW, Kurobe H, Tara S, Chan C, Rocco KA, Shinoka T, Sinusas AJ, Breuer CK: Targeted imaging of matrix metalloproteinase activity in the evaluation of remodeling tissue-engineered vascular grafts implanted in a growing lamb model. J Thorac Cardiovasc Surg. 2014 Nov; 2014 May 21. PMID: 24952823

Burg MM, Meadows J, Shimbo D, Davidson KW, Schwartz JE, Soufer R: Confluence of depression and acute psychological stress among patients with stable coronary heart disease: effects on myocardial perfusion. J Am Heart Assoc. 2014 Oct 30; 2014 Oct 30. PMID: 25359402

Chan C, Harris M, Le M, Biondi J, Grobshtein Y, Liu YH, Sinusas AJ, Liu C: End-expiration respiratory gating for a high-resolution stationary cardiac SPECT system. Phys Med Biol. 2014 Oct 21; 2014 Sep 26. PMID: 25256033

Liu C, Sinusas AJ: Is assessment of absolute myocardial perfusion with SPECT ready for prime time? J Nucl Med. 2014 Oct; 2014 Sep 18. PMID: 25236351

Morrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M, Bender JR: Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exp Med. 2014 Sep 22; 2014 Sep 1. PMID: 25180062

Sinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE, Lee LV: Biodistribution and radiation dosimetry of LMI1195: first-in-human study of a novel 18F-labeled tracer for imaging myocardial innervation. J Nucl Med. 2014 Sep; 2014 Jul 3. PMID: 24994931

Mozid AM, Holstensson M, Choudhury T, Ben-Haim S, Allie R, Martin J, Sinusas AJ, Hutton BF, Mathur A: Clinical feasibility study to detect angiogenesis following bone marrow stem cell transplantation in chronic ischaemic heart failure. Nucl Med Commun. 2014 Aug. PMID: 24769888

Mehra VC, Jackson E, Zhang XM, Jiang XC, Dobrucki LW, Yu J, Bernatchez P, Sinusas AJ, Shulman GI, Sessa WC, Yarovinsky TO, Bender JR: Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis. Am J Pathol. 2014 May; 2014 Mar 5. PMID: 24606881

Sinusas AJ, Spatz ES: Reframing the interpretation and application of exercise electrocardiography. J Am Coll Cardiol. 2014 Apr 8; 2014 Feb 5. PMID: 24509274

Safdar B, Bezek SK, Sinusas AJ, Russell RR, Klein MR, Dziura JD, D'Onofrio G: Elevated CK-MB with a normal troponin does not predict 30-day adverse cardiac events in emergency department chest pain observation unit patients. Crit Pathw Cardiol. 2014 Mar. PMID: 24526146

Huang X, Dione DP, Compas CB, Papademetris X, Lin BA, Bregasi A, Sinusas AJ, Staib LH, Duncan JS: Contour tracking in echocardiographic sequences via sparse representation and dictionary learning. Med Image Anal. 2014 Feb; 2013 Nov 6. PMID: 24292554

Stacy MR, Yu da Y, Maxfield MW, Jaba IM, Jozwik BP, Zhuang ZW, Lin BA, Hawley CL, Caracciolo CM, Pal P, Tirziu D, Sampath S, Sinusas AJ: Multimodality imaging approach for serial assessment of regional changes in lower extremity arteriogenesis and tissue perfusion in a porcine model of peripheral arterial disease. Circ Cardiovasc Imaging. 2014 Jan; 2013 Oct 29. PMID: 24170237

Li S, Sinusas AJ, Dobrucki LW, Liu YH: New approach to quantification of molecularly targeted radiotracer uptake from hybrid cardiac SPECT/CT: methodology and validation. J Nucl Med. 2013 Dec; 2013 Nov 12. PMID: 24221992

Stacy MR, Zhou W, Sinusas AJ: Radiotracer imaging of peripheral vascular disease. J Nucl Med. 2013 Dec; 2013 Oct 7. PMID: 24101686

Zhang Z, Friedman D, Dione DP, Lin BA, Duncan JS, Sinusas AJ, Sampath S: Assessment of left ventricular 2D flow pathlines during early diastole using spatial modulation of magnetization with polarity alternating velocity encoding: a study in normal volunteers and canine animals with myocardial infarction. Magn Reson Med. 2013 Sep; 2012 Oct 8. PMID: 23044637

Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D: NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. J Clin Invest. 2013 Apr. PMID: 23454748

Huang X, Dione DP, Lin BA, Bregasi A, Sinusas AJ, Duncan JS: Segmentation of 4D echocardiography using stochastic online dictionary learning. Med Image Comput Comput Assist Interv. 2013. PMID: 24505744

Tandon S, Wackers FJ, Inzucchi SE, Bansal S, Staib LH, Chyun DA, Davey JA, Young LH, DIAD Investigators: Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: results from the DIAD study. Diab Vasc Dis Res. 2012 Apr; 2012 Jan 6. PMID: 22228772

Hedhli N, Dobrucki LW, Kalinowski A, Zhuang ZW, Wu X, Russell RR 3rd, Sinusas AJ, Russell KS: Endothelial-derived neuregulin is an important mediator of ischaemia-induced angiogenesis and arteriogenesis. Cardiovasc Res. 2012 Mar 1; 2011 Dec 26. PMID: 22200588

Stacy MR, Maxfield MW, Sinusas AJ: Targeted molecular imaging of angiogenesis in PET and SPECT: a review. Yale J Biol Med. 2012 Mar; 2012 Mar 29. PMID: 22461745

Pearlman PC, Tagare HD, Lin BA, Sinusas AJ, Duncan JS: Segmentation of 3D radio frequency echocardiography using a spatio-temporal predictor. Med Image Anal. 2012 Feb; 2011 Oct 14. PMID: 22078842

Huang X, Dione DP, Compas CB, Papademetris X, Lin BA, Sinusas AJ, Duncan JS: A dynamical appearance model based on multiscale sparse representation: segmentation of the left ventricle from 4D echocardiography. Med Image Comput Comput Assist Interv. 2012. PMID: 23286114

Razavian M, Marfatia R, Mongue-Din H, Tavakoli S, Sinusas AJ, Zhang J, Nie L, Sadeghi MM: Integrin-targeted imaging of inflammation in vascular remodeling. Arterioscler Thromb Vasc Biol. 2011 Dec; 2011 Sep 22. PMID: 21940943

Zhang Z, Dione DP, Brown PB, Shapiro EM, Sinusas AJ, Sampath S: Assessment of early diastolic strain-velocity temporal relationships using spatial modulation of magnetization with polarity alternating velocity encoding (SPAMM-PAV). Magn Reson Med. 2011 Dec; 2011 May 31. PMID: 21630348

Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki LW, Sinusas AJ, Azure M, Robinson S, Sadeghi MM: Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation. J Nucl Med. 2011 Nov; 2011 Oct 3. PMID: 21969358

Criscione JM, Dobrucki LW, Zhuang ZW, Papademetris X, Simons M, Sinusas AJ, Fahmy TM: Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging. Bioconjug Chem. 2011 Sep 21; 2011 Sep 6. PMID: 21851119

Sahul ZH, Mukherjee R, Song J, McAteer J, Stroud RE, Dione DP, Staib L, Papademetris X, Dobrucki LW, Duncan JS, Spinale FG, Sinusas AJ: Targeted imaging of the spatial and temporal variation of matrix metalloproteinase activity in a porcine model of postinfarct remodeling: relationship to myocardial dysfunction. Circ Cardiovasc Imaging. 2011 Jul; 2011 Apr 19. PMID: 21505092

Sinusas AJ, Thomas JD, Mills G: The future of molecular imaging. JACC Cardiovasc Imaging. 2011 Jul. PMID: 21757172

Liu YH, Sahul Z, Weyman CA, Dione DP, Dobrucki WL, Mekkaoui C, Brennan MP, Ryder WJ, Sinusas AJ: Accuracy and reproducibility of absolute quantification of myocardial focal tracer uptake from molecularly targeted SPECT/CT: a canine validation. J Nucl Med. 2011 Mar; 2011 Feb 14. PMID: 21321271

Suh JW, Scheinost D, Dione DP, Dobrucki LW, Sinusas AJ, Papademetris X: A non-rigid registration method for serial lower extremity hybrid SPECT/CT imaging. Med Image Anal. 2011 Feb; 2010 Sep 24. PMID: 20869902

Pearlman PC, Tagare HD, Lin BA, Sinusas AJ, Duncan JS: Segmentation of 3D RF echocardiography using a multiframe spatio-temporal predictor. Inf Process Med Imaging. 2011. PMID: 21761644

Jiang Y, Zhuang ZW, Sinusas AJ, Staib LH, Papademetris X: Vessel connectivity using Murray's hypothesis. Med Image Comput Comput Assist Interv. 2011. PMID: 22003740

Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM: Molecular imaging of matrix metalloproteinase activation to predict murine aneurysm expansion in vivo. J Nucl Med. 2010 Jul; 2010 Jun 16. PMID: 20554725

Jiang Y, Zhuang Z, Sinusas AJ, Papademetris X: Vascular Tree Reconstruction by Minimizing A Physiological Functional Cost. Conf Comput Vis Pattern Recognit Workshops. 2010 Jun 13. PMID: 21755061

Dobrucki LW, Tsutsumi Y, Kalinowski L, Dean J, Gavin M, Sen S, Mendizabal M, Sinusas AJ, Aikawa R: Analysis of angiogenesis induced by local IGF-1 expression after myocardial infarction using microSPECT-CT imaging. J Mol Cell Cardiol. 2010 Jun; 2009 Oct 20. PMID: 19850049

Zhu Y, Papademetris X, Sinusas AJ, Duncan JS: A coupled deformable model for tracking myocardial borders from real-time echocardiography using an incompressibility constraint. Med Image Anal. 2010 Jun; 2010 Mar 15. PMID: 20350833

Dobrucki LW, de Muinck ED, Lindner JR, Sinusas AJ: Approaches to multimodality imaging of angiogenesis. J Nucl Med. 2010 May 1. PMID: 20457795

Sinusas AJ: Multimodality cardiovascular molecular imaging: an overview. J Nucl Med. 2010 May 1; 2010 Apr 15. PMID: 20395344

Dobrucki LW, de Muinck ED, Lindner JR, Sinusas AJ: Approaches to Multimodality Imaging of Angiogenesis. J Nucl Med. 2010 Apr 15; 2010 Apr 15. PMID: 20395346

Suh JW, Scheinost D, Qian X, Sinusas AJ, Breuer CK, Papademetris X: SERIAL NONRIGID VASCULAR REGISTRATION USING WEIGHTED NORMALIZED MUTUAL INFORMATION. Proc IEEE Int Symp Biomed Imaging. 2010 Apr 14. PMID: 21479163

Sinusas AJ: Molecular imaging in nuclear cardiology: translating research concepts into clinical applications. Q J Nucl Med Mol Imaging. 2010 Apr. PMID: 20588216

Zhu Y, Papademetris X, Sinusas AJ, Duncan JS: Segmentation of the left ventricle from cardiac MR images using a subject-specific dynamical model. IEEE Trans Med Imaging. 2010 Mar; 2009 Sep 29. PMID: 19789107

Morrison AR, Sinusas AJ: Advances in radionuclide molecular imaging in myocardial biology. J Nucl Cardiol. 2010 Jan-Feb. PMID: 20012514

Pearlman PC, Tagare HD, Sinusas AJ, Duncan JS: 3D radio frequency ultrasound cardiac segmentation using a linear predictor. Med Image Comput Comput Assist Interv. 2010. PMID: 20879268

Dobrucki LW, Sinusas AJ: PET and SPECT in cardiovascular molecular imaging. Nat Rev Cardiol. 2010 Jan; 2009 Nov 24. PMID: 19935740

Dobrucki LW, Meoli DF, Hu J, Sadeghi MM, Sinusas AJ: Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury. J Physiol Pharmacol. 2009 Oct. PMID: 20083860

Mekkaoui C, Jadbabaie F, Dione DP, Meoli DF, Purushothaman K, Belardinelli L, Sinusas AJ: Effects of adenosine and a selective A2A adenosine receptor agonist on hemodynamic and thallium-201 and technetium-99m-sestaMIBI biodistribution and kinetics. JACC Cardiovasc Imaging. 2009 Oct. PMID: 19833310

Dobrucki LW, Dione DP, Kalinowski L, Dione D, Mendizabal M, Yu J, Papademetris X, Sessa WC, Sinusas AJ: Serial noninvasive targeted imaging of peripheral angiogenesis: validation and application of a semiautomated quantitative approach. J Nucl Med. 2009 Aug; 2009 Jul 17. PMID: 19617325

Ozcan C, Zaret BL: Dobutamine stress test and beta-agonist - a potential concern for nuclear cardiology testing: a case report. Cases J. 2009 Jul 9; 2009 Jul 9. PMID: 19829971

Morrison AR, Sinusas AJ: New molecular imaging targets to characterize myocardial biology. Cardiol Clin. 2009 May. PMID: 19306773

Young LH, Wackers FJ, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Heller GV, Iskandrian AE, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE, DIAD Investigators: Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial. JAMA. 2009 Apr 15. PMID: 19366774

Brennan MP, Sinusas AJ, Horvath TL, Collins JG, Harding MJ: Correlation between body weight changes and postoperative pain in rats treated with meloxicam or buprenorphine. Lab Anim (NY). 2009 Mar. PMID: 19229225

Qian X, Brennan MP, Dione DP, Dobrucki WL, Jackowski MP, Breuer CK, Sinusas AJ, Papademetris X: A non-parametric vessel detection method for complex vascular structures. Med Image Anal. 2009 Feb; 2008 Jun 14. PMID: 18678521

Zhu Y, Papademetris X, Sinusas AJ, Duncan JS: A Dynamical Shape Prior for LV Segmentation from RT3D Echocardiography. Med Image Comput Comput Assist Interv. 2009. PMID: 20054422

Suh JW, Scheinost D, Dione DP, Dobrucki LW, Sinusas AJ, Papademetris X: A non-rigid registration method for serial microCT mouse hindlimb images. Med Image Comput Comput Assist Interv. 2009. PMID: 20426048

Zhu Y, Papademetris X, Sinusas AJ, Duncan JS: A dynamical shape prior for LV segmentation from RT3D echocardiography. Med Image Comput Comput Assist Interv. 2009. PMID: 20425989

Zaret BL, Zaret M: Purim CPR. Psychosom Med. 2009 Jan; 2009 Jan 5. PMID: 19124619

Zhang J, Nie L, Razavian M, Ahmed M, Dobrucki LW, Asadi A, Edwards DS, Azure M, Sinusas AJ, Sadeghi MM: Molecular imaging of activated matrix metalloproteinases in vascular remodeling. Circulation. 2008 Nov 4; 2008 Oct 20. PMID: 18936327

Sinusas AJ, Bengel F, Nahrendorf M, Epstein FH, Wu JC, Villanueva FS, Fayad ZA, Gropler RJ: Multimodality cardiovascular molecular imaging, part I. Circ Cardiovasc Imaging. 2008 Nov. PMID: 19808549

Joshi A, Qian X, Dione DP, Bulsara KR, Breuer CK, Sinusas AJ, Papademetris X: Effective visualization of complex vascular structures using a non-parametric vessel detection method. IEEE Trans Vis Comput Graph. 2008 Nov-Dec. PMID: 18989016

Sinusas AJ: Cardiovascular molecular imaging: promoting utilization and outreach. J Nucl Med. 2008 Jun. PMID: 18511831

Kalinowski L, Dobrucki LW, Meoli DF, Dione DP, Sadeghi MM, Madri JA, Sinusas AJ: Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction. J Appl Physiol (1985). 2008 May; 2008 Mar 20. PMID: 18356482

Roh JD, Nelson GN, Brennan MP, Mirensky TL, Yi T, Hazlett TF, Tellides G, Sinusas AJ, Pober JS, Saltzman WM, Kyriakides TR, Breuer CK: Small-diameter biodegradable scaffolds for functional vascular tissue engineering in the mouse model. Biomaterials. 2008 Apr; 2007 Dec 27. PMID: 18164056

Zhu Y, Papademetris X, Sinusas AJ, Duncan JS: Bidirectional segmentation of three-dimensional cardiac MR images using a subject-specific dynamical model. Med Image Comput Comput Assist Interv. 2008. PMID: 18982636

Chung G, Sinusas AJ: Imaging of matrix metalloproteinase activation and left ventricular remodeling. Curr Cardiol Rep. 2007 Apr. PMID: 17430681

Dobrucki LW, Sinusas AJ: Imaging angiogenesis. Curr Opin Biotechnol. 2007 Feb; 2007 Jan 19. PMID: 17240135

Luo D, Luo Y, He Y, Zhang H, Zhang R, Li X, Dobrucki WL, Sinusas AJ, Sessa WC, Min W: Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis. Am J Pathol. 2006 Nov. PMID: 17071609

Li J, Coven DL, Miller EJ, Hu X, Young ME, Carling D, Sinusas AJ, Young LH: Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart. Am J Physiol Heart Circ Physiol. 2006 Oct; 2006 Apr 28. PMID: 16648175

Russell RR 3rd, Zaret BL: Nuclear cardiology: present and future. Curr Probl Cardiol. 2006 Sep. PMID: 16935694

He Y, Luo Y, Tang S, Rajantie I, Salven P, Heil M, Zhang R, Luo D, Li X, Chi H, Yu J, Carmeliet P, Schaper W, Sinusas AJ, Sessa WC, Alitalo K, Min W: Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest. 2006 Sep; 2006 Aug 24. PMID: 16932810

Yu W, Yan P, Sinusas AJ, Thiele K, Duncan JS: Towards pointwise motion tracking in echocardiographic image sequences--comparing the reliability of different features for speckle tracking. Med Image Anal. 2006 Aug; 2006 Mar 30. PMID: 16574465

Su H, Spinale FG, Dobrucki LW, Song J, Hua J, Sweterlitsch S, Dione DP, Cavaliere P, Chow C, Bourke BN, Hu XY, Azure M, Yalamanchili P, Liu R, Cheesman EH, Robinson S, Edwards DS, Sinusas AJ: Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation. 2005 Nov 15; 2005 Nov 7. PMID: 16275862

Zhang J, Krassilnikova S, Gharaei AA, Fassaei HR, Esmailzadeh L, Asadi A, Edwards DS, Harris TD, Azure M, Tellides G, Sinusas AJ, Zaret BL, Bender JR, Sadeghi MM: Alphavbeta3-targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study. FASEB J. 2005 Nov; 2005 Sep 8. PMID: 16150802

Hua J, Dobrucki LW, Sadeghi MM, Zhang J, Bourke BN, Cavaliere P, Song J, Chow C, Jahanshad N, van Royen N, Buschmann I, Madri JA, Mendizabal M, Sinusas AJ: Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia. Circulation. 2005 Jun 21; 2005 Jun 13. PMID: 15956134

Dobrucki LW, Sinusas AJ: Molecular cardiovascular imaging. Curr Cardiol Rep. 2005 Mar. PMID: 15717960

Dobrucki LW, Sinusas AJ: Molecular imaging. A new approach to nuclear cardiology. Q J Nucl Med Mol Imaging. 2005 Mar. PMID: 15724140

Liu YH, Sinusas AJ, Khaimov D, Gebuza BI, Wackers FJ: New hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: methodology and validation. J Nucl Cardiol. 2005 Jan-Feb. PMID: 15682366

Papademetris X, Dione DP, Dobrucki LW, Staib LH, Sinusas AJ: Articulated rigid registration for serial lower-limb mouse imaging. Med Image Comput Comput Assist Interv. 2005. PMID: 16686048

Jackowski M, Papademetris X, Dobrucki LW, Sinusas AJ, Staib LH: Characterizing vascular connectivity from microCT images. Med Image Comput Comput Assist Interv. 2005. PMID: 16686021

Li S, Dobrucki LW, Sinusas AJ, Liu YH: A new method for SPECT quantification of targeted radiotracers uptake in the myocardium. Med Image Comput Comput Assist Interv. 2005. PMID: 16686019

Yan P, Lin N, Sinusas AJ, Duncan JS: A boundary element-based approach to analysis of LV deformation. Med Image Comput Comput Assist Interv. 2005. PMID: 16685917

Dobrucki LW, Sinusas AJ: Cardiovascular molecular imaging. Semin Nucl Med. 2005 Jan. PMID: 15645396

Sinusas AJ: Imaging of angiogenesis. J Nucl Cardiol. 2004 Sep-Oct. PMID: 15472646

Sadeghi MM, Krassilnikova S, Zhang J, Gharaei AA, Fassaei HR, Esmailzadeh L, Kooshkabadi A, Edwards S, Yalamanchili P, Harris TD, Sinusas AJ, Zaret BL, Bender JR: Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo. Circulation. 2004 Jul 6; 2004 Jun 21. PMID: 15210600

Zaret BL: Second Annual Mario S. Verani, MD, Memorial Lecture: Nuclear cardiology, the next 10 years. J Nucl Cardiol. 2004 Jul-Aug. PMID: 15295408

Meoli DF, Sadeghi MM, Krassilnikova S, Bourke BN, Giordano FJ, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri JA, Zaret BL, Sinusas AJ: Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest. 2004 Jun. PMID: 15199403

Sadeghi MM, Schechner JS, Krassilnikova S, Gharaei AA, Zhang J, Kirkiles-Smith N, Sinusas AJ, Zaret BL, Bender JR: Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature. Transplant Proc. 2004 Jun. PMID: 15251390

Liu YH, Lam PT, Sinusas AJ, Wackers FJ: Differential effect of 180 degrees and 360 degrees acquisition orbits on the accuracy of SPECT imaging: quantitative evaluation in phantoms. J Nucl Med. 2002 Aug. PMID: 12163639

Papademetris X, Sinusas AJ, Dione DP, Constable RT, Duncan JS: Estimation of 3-D left ventricular deformation from medical images using biomechanical models. IEEE Trans Med Imaging. 2002 Jul. PMID: 12374316

Shi CQ, Young LH, Daher E, DiBella EV, Liu YH, Heller EN, Zoghbi S, Wackers FJ, Soufer R, Sinusas AJ: Correlation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemia. J Nucl Med. 2002 Mar. PMID: 11884504

Sinusas AJ, Papademetris X, Constable RT, Dione DP, Slade MD, Shi P, Duncan JS: Quantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images. Am J Physiol Heart Circ Physiol. 2001 Aug. PMID: 11454574

Kailasnath P, Sinusas AJ: Comparison of Tl-201 with Tc-99m-labeled myocardial perfusion agents: technical, physiologic, and clinical issues. J Nucl Cardiol. 2001 Jul-Aug. PMID: 11481571

Kailasnath P, Sinusas AJ: Technetium-99m-labeled myocardial perfusion agents: Are they better than thallium-201? Cardiol Rev. 2001 May-Jun. PMID: 11304401

Jain D, Joska T, Lee FA, Burg M, Lampert R, Zaret BL: Day-to-day reproducibility of mental stress-induced abnormal left ventricular function response in patients with coronary artery disease and its relationship to autonomic activation. J Nucl Cardiol. 2001 May-Jun. PMID: 11391305

Heller EN, Staib LH, Dione DP, Constable RT, Shi CQ, Duncan JS, Sinusas AJ: A new method for quantification of spatial and temporal parameters of endocardial motion: evaluation of experimental infarction using magnetic resonance imaging. Can J Cardiol. 2001 Mar. PMID: 11264564

Papademetris X, Sinusas AJ, Dione DP, Duncan JS: Estimation of 3D left ventricular deformation from echocardiography. Med Image Anal. 2001 Mar. PMID: 11231174

Caulin-Glaser T, Blum M, Schmeizl R, Prigerson HG, Zaret B, Mazure CM: Gender differences in referral to cardiac rehabilitation programs after revascularization. J Cardiopulm Rehabil. 2001 Jan-Feb. PMID: 11271654

Vallejo E, Dione DP, Sinusas AJ, Wackers FJ: Assessment of left ventricular ejection fraction with quantitative gated SPECT: accuracy and correlation with first-pass radionuclide angiography. J Nucl Cardiol. 2000 Sep-Oct. PMID: 11083195

Vallejo E, Dione DP, Bruni WL, Constable RT, Borek PP, Soares JP, Carr JG, Condos SG, Wackers FJ, Sinusas AJ: Reproducibility and accuracy of gated SPECT for determination of left ventricular volumes and ejection fraction: experimental validation using MRI. J Nucl Med. 2000 May. PMID: 10809204

Daher E, Dione DP, Heller EN, Holahan J, DeMan P, Shen M, Hu J, Sinusas AJ: Acute ischemic dysfunction alters coronary flow reserve in remote nonischemic regions: potential mechanical etiology identified in an acute canine model. J Nucl Cardiol. 2000 Mar-Apr. PMID: 10796000

Zaret BL, Strauss HW: The past, present and future of nuclear cardiology. Rev Port Cardiol. 2000 Feb. PMID: 10750434

Wu JC, Yun JJ, Dione DP, Heller EN, Deckelbaum LI, Sinusas AJ: Severe regional ischemia alters coronary flow reserve in the remote perfusion area. J Nucl Cardiol. 2000 Jan-Feb. PMID: 10698234

Shen MY, Liu YH, Sinusas AJ, Fetterman R, Bruni W, Drozhinin OE, Zaret BL, Wackers FJ: Quantification of regional myocardial wall thickening on electrocardiogram-gated SPECT imaging. J Nucl Cardiol. 1999 Nov-Dec. PMID: 10608585

Sinusas AJ: The potential for myocardial imaging with hypoxia markers. Semin Nucl Med. 1999 Oct. PMID: 10534235

Young LH, Russell RR 3rd, Yin R, Caplan MJ, Ren J, Bergeron R, Shulman GI, Sinusas AJ: Regulation of myocardial glucose uptake and transport during ischemia and energetic stress. Am J Cardiol. 1999 Jun 17. PMID: 10750583

Liu YH, Sinusas AJ, DeMan P, Zaret BL, Wackers FJ: Quantification of SPECT myocardial perfusion images: methodology and validation of the Yale-CQ method. J Nucl Cardiol. 1999 Mar-Apr. PMID: 10327104

Russell RR 3rd, Yin R, Caplan MJ, Hu X, Ren J, Shulman GI, Sinusas AJ, Young LH: Additive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivo. Circulation. 1998 Nov 17. PMID: 9815873

Mattera JA, Arain SA, Sinusas AJ, Finta L, Wackers FJ: Exercise testing with myocardial perfusion imaging in patients with normal baseline electrocardiograms: cost savings with a stepwise diagnostic strategy. J Nucl Cardiol. 1998 Sep-Oct. PMID: 9796897

Caulin-Glaser T, Farrell WJ, Pfau SE, Zaret B, Bunger K, Setaro JF, Brennan JJ, Bender JR, Cleman MW, Cabin HS, Remetz MS: Modulation of circulating cellular adhesion molecules in postmenopausal women with coronary artery disease. J Am Coll Cardiol. 1998 Jun. PMID: 9626834

Soufer R, Bremner JD, Arrighi JA, Cohen I, Zaret BL, Burg MM, Goldman-Rakic P: Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease. Proc Natl Acad Sci U S A. 1998 May 26. PMID: 9600987

Jain D, Shaker SM, Burg M, Wackers FJ, Soufer R, Zaret BL: Effects of mental stress on left ventricular and peripheral vascular performance in patients with coronary artery disease. J Am Coll Cardiol. 1998 May. PMID: 9581726

Sinusas AJ: Experimental evaluation of radiotracers: role of intact biological models. J Nucl Cardiol. 1998 Mar-Apr. PMID: 9588669

Wu JC, Yun JJ, Heller EN, Dione DP, DeMan P, Liu YH, Zaret BL, Wackers FJ, Sinusas AJ: Limitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging. J Nucl Med. 1998 Mar. PMID: 9529285

Mehta ID, Weinberg J, Jones MF, Tellides G, Kopf GS, Shaw RK, Zaret BL, Elefteriades JA: Should angiographically disease-free saphenous vein grafts be replaced at the time of redo coronary artery bypass grafting? Ann Thorac Surg. 1998 Jan. PMID: 9456088

Heller EN, DeMan P, Liu YH, Dione DP, Zubal IG, Wackers FJ, Sinusas AJ: Extracardiac activity complicates quantitative cardiac SPECT imaging using a simultaneous transmission-emission approach. J Nucl Med. 1997 Dec. PMID: 9430462

Kocheril AG, Bokhari SA, Batsford WP, Sinusas AJ: Long QTc and torsades de pointes in human immunodeficiency virus disease. Pacing Clin Electrophysiol. 1997 Nov. PMID: 9392812

Gradel C, Jain D, Batsford WP, Wackers FJ, Zaret BL: Relationship of scar and ischemia to the results of programmed electrophysiological stimulation in patients with coronary artery disease. J Nucl Cardiol. 1997 Sep-Oct. PMID: 9362014

Jain D, Thompson B, Wackers FJ, Zaret BL: Relevance of increased lung thallium uptake on stress imaging in patients with unstable angina and non-Q wave myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI)-IIIB Study. J Am Coll Cardiol. 1997 Aug. PMID: 9247514

Elefteriades JA, Morales DL, Gradel C, Tollis G Jr, Levi E, Zaret BL: Results of coronary artery bypass grafting by a single surgeon in patients with left ventricular ejection fractions < or = 30%. Am J Cardiol. 1997 Jun 15. PMID: 9202343

Young LH, Renfu Y, Russell R, Hu X, Caplan M, Ren J, Shulman GI, Sinusas AJ: Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo. Circulation. 1997 Jan 21. PMID: 9008459

Ng CK, Sinusas AJ, Zaret BL, Soufer R: Kinetic analysis of technetium-99m-labeled nitroimidazole (BMS-181321) as a tracer of myocardial hypoxia. Circulation. 1995 Sep 1. PMID: 7648674

Jain D, Burg M, Soufer R, Zaret BL: Prognostic implications of mental stress-induced silent left ventricular dysfunction in patients with stable angina pectoris. Am J Cardiol. 1995 Jul 1. PMID: 7793399

Zaret BL, Wackers FJ, Terrin ML, Forman SA, Williams DO, Knatterud GL, Braunwald E: Value of radionuclide rest and exercise left ventricular ejection fraction in assessing survival of patients after thrombolytic therapy for acute myocardial infarction: results of Thrombolysis in Myocardial Infarction (TIMI) phase II study. The TIMI Study Group. J Am Coll Cardiol. 1995 Jul. PMID: 7797778

Soufer R, Dey HM, Ng CK, Zaret BL: Comparison of sestamibi single-photon emission computed tomography with positron emission tomography for estimating left ventricular myocardial viability. Am J Cardiol. 1995 Jun 15. PMID: 7778542

Shi CQ, Sinusas AJ, Dione DP, Singer MJ, Young LH, Heller EN, Rinker BD, Wackers FJ, Zaret BL: Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia. J Nucl Med. 1995 Jun. PMID: 7769431

Jain D, Zaret BL: Nuclear imaging techniques for the assessment of myocardial viability. Cardiol Clin. 1995 Feb. PMID: 7796431

Soufer R, Dey HM, Lawson AJ, Wackers FJ, Zaret BL: Relationship between reverse redistribution on planar thallium scintigraphy and regional myocardial viability: a correlative PET study. J Nucl Med. 1995 Feb. PMID: 7830110

Zaret BL, Rigo P, Wackers FJ, Hendel RC, Braat SH, Iskandrian AS, Sridhara BS, Jain D, Itti R, Serafini AN: Myocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group. Circulation. 1995 Jan 15. PMID: 7805233

Raiker K, Sinusas AJ, Wackers FJ, Zaret BL: One-year prognosis of patients with normal planar or single-photon emission computed tomographic technetium 99m-labeled sestamibi exercise imaging. J Nucl Cardiol. 1994 Sep-Oct. PMID: 9420729

Constable RT, Rath KM, Sinusas AJ, Gore JC: Development and evaluation of tracking algorithms for cardiac wall motion analysis using phase velocity MR imaging. Magn Reson Med. 1994 Jul. PMID: 8084235

Sinusas AJ, Bergin JD, Edwards NC, Watson DD, Ruiz M, Makuch RW, Smith WH, Beller GA: Redistribution of 99mTc-sestamibi and 201Tl in the presence of a severe coronary artery stenosis. Circulation. 1994 May. PMID: 8181159

Sinusas AJ, Shi Q, Saltzberg MT, Vitols P, Jain D, Wackers FJ, Zaret BL: Technetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia. J Nucl Med. 1994 Apr. PMID: 8151391

Haronian HL, Sinusas AJ, Remetz MS, Brennan JJ, Cabin HS, Zaret BL, Wackers FJ: Effects of altered left ventricular geometry on quantitative technetium 99m sestamibi defect size in humans: perfusion imaging during coronary angioplasty. J Nucl Cardiol. 1994 Mar-Apr. PMID: 9420682

Sinusas AJ, Shi Q, Vitols PJ, Fetterman RC, Maniawski P, Zaret BL, Wackers FJ: Impact of regional ventricular function, geometry, and dobutamine stress on quantitative 99mTc-sestamibi defect size. Circulation. 1993 Nov. PMID: 8222117

Elefteriades JA, Tolis G Jr, Levi E, Mills LK, Zaret BL: Coronary artery bypass grafting in severe left ventricular dysfunction: excellent survival with improved ejection fraction and functional state. J Am Coll Cardiol. 1993 Nov 1. PMID: 8227799

Marmor A, Jain D, Cohen LS, Nevo E, Wackers FJ, Zaret BL: Left ventricular peak power during exercise: a noninvasive approach for assessment of contractile reserve. J Nucl Med. 1993 Nov. PMID: 8229228

Haronian HL, Remetz MS, Sinusas AJ, Baron JM, Miller HI, Cleman MW, Zaret BL, Wackers FJ: Myocardial risk area defined by technetium-99m sestamibi imaging during percutaneous transluminal coronary angioplasty: comparison with coronary angiography. J Am Coll Cardiol. 1993 Oct. PMID: 8409038

Zaret BL, Wackers FJ: Nuclear cardiology (2). N Engl J Med. 1993 Sep 16. PMID: 8355745

Zaret BL, Wackers FJ: Nuclear cardiology (1). N Engl J Med. 1993 Sep 9. PMID: 8350888

Jain D, Wackers FJ, Mattera J, McMahon M, Sinusas AJ, Zaret BL: Biokinetics of technetium-99m-tetrofosmin: myocardial perfusion imaging agent: implications for a one-day imaging protocol. J Nucl Med. 1993 Aug. PMID: 8326381

Sinusas AJ, Zaret BL: Introduction: Are conventional imaging strategies used following myocardial infarction equally appropriate in the thrombolytic era? Am J Card Imaging. 1993 Mar. PMID: 10150106

Sinusas AJ, Wackers FJ: Assessing myocardial reperfusion with technetium-99m-labeled myocardial perfusion agents: basic concepts and clinical applications. Am J Card Imaging. 1993 Mar. PMID: 10148381

Setaro JF, Soufer R, Remetz MS, Perlmutter RA, Zaret BL: Long-term outcome in patients with congestive heart failure and intact systolic left ventricular performance. Am J Cardiol. 1992 May 1. PMID: 1575193

Schulman DS, Biondi JW, Zohgbi S, Cecchetti A, Zaret BL, Soufer R: Left ventricular diastolic function during positive end-expiratory pressure. Impact of right ventricular ischemia and ventricular interaction. Am Rev Respir Dis. 1992 Mar. PMID: 1546829

Jain D, Zaret BL: Assessment of right ventricular function. Role of nuclear imaging techniques. Cardiol Clin. 1992 Feb. PMID: 1739959

Kayden DS, Sigal S, Soufer R, Mattera J, Zaret BL, Wackers FJ: Thallium-201 for assessment of myocardial viability: quantitative comparison of 24-hour redistribution imaging with imaging after reinjection at rest. J Am Coll Cardiol. 1991 Nov 15. PMID: 1939949

Bell L, Zaret BL, Rutlen DL: Influence of alpha-adrenergic receptor stimulation on splanchnic intravascular volume in conscious humans. Acta Physiol Scand. 1991 Sep. PMID: 1659775

Kayden DS, Remetz MS, Cabin HS, Deckelbaum LI, Cleman MW, Wackers FJ, Zaret BL: Validation of continuous radionuclide left ventricular functioning monitoring in detecting silent myocardial ischemia during balloon angioplasty of the left anterior descending coronary artery. Am J Cardiol. 1991 Jun 15. PMID: 2042565

Young LH, McNulty PH, Morgan C, Deckelbaum LI, Zaret BL, Barrett EJ: Myocardial protein turnover in patients with coronary artery disease. Effect of branched chain amino acid infusion. J Clin Invest. 1991 Feb. PMID: 1991838

Duncan JS, Lee FA, Smeulders AM, Zaret BL: A bending energy model for measurement of cardiac shape deformity. IEEE Trans Med Imaging. 1991. PMID: 18222832

Revkin JH, Young LH, Stirewalt WS, Dahl DM, Gelfand RA, Zaret BL, Barrett EJ: In vivo measurement of myocardial protein turnover using an indicator dilution technique. Circ Res. 1990 Oct. PMID: 2208613

Jain D, Zaret BL: Antimyosin cardiac imaging in acute myocarditis. J Am Coll Cardiol. 1990 Jul. PMID: 2358582

Sinusas AJ, Beller GA, Watson DD: Cardiac imaging with technetium 99m-labeled isonitriles. J Thorac Imaging. 1990 Jul. PMID: 2194038

Schulman DS, Biondi JW, Zohgbi S, Zaret BL, Soufer R: Coronary flow limits right ventricular performance during positive end-expiratory pressure. Am Rev Respir Dis. 1990 Jun. PMID: 2190508

Kayden DS, Wackers FJ, Zaret BL: Silent left ventricular dysfunction during routine activity after thrombolytic therapy for acute myocardial infarction. J Am Coll Cardiol. 1990 Jun. PMID: 2345230

Bell L, Hennecken J, Zaret BL, Rutlen DL: Alpha-adrenergic regulation of splanchnic volume and cardiac output in the dog. Acta Physiol Scand. 1990 Mar. PMID: 2158209

Zaret BL, Kayden DS: Ambulatory monitoring of left ventricular function: a new modality for assessing silent myocardial ischemia. Adv Cardiol. 1990. PMID: 2220442

Zaret BL, Wackers FJ: Myocardial perfusion scintigraphy as an aid in understanding electrocardiographic changes of ischemia and infarction. Ann N Y Acad Sci. 1990. PMID: 2221682

Soufer R, Zaret BL: Positron emission tomography and the quantitative assessment of regional myocardial blood flow. J Am Coll Cardiol. 1990 Jan. PMID: 2295721

Young LH, Zaret BL, Barrett EJ: Physiologic hyperinsulinemia stimulates lactate extraction by heart muscle in the conscious dog. Metabolism. 1989 Nov. PMID: 2682138

Schulman DS, Biondi JW, Matthay RA, Zaret BL, Soufer R: Differing responses in right and left ventricular filling, loading and volumes during positive end-expiratory pressure. Am J Cardiol. 1989 Oct 1. PMID: 2679024

Wackers FJ, Gibbons RJ, Verani MS, Kayden DS, Pellikka PA, Behrenbeck T, Mahmarian JJ, Zaret BL: Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: efficacy for noninvasive assessment of thrombolytic therapy. J Am Coll Cardiol. 1989 Oct. PMID: 2507612

LaVeau PJ, Rozanski A, Krantz DS, Cornell CE, Cattanach L, Zaret BL, Wackers FJ: Transient left ventricular dysfunction during provocative mental stress in patients with coronary artery disease. Am Heart J. 1989 Jul. PMID: 2741776

Wackers FJ, Terrin ML, Kayden DS, Knatterud G, Forman S, Braunwald E, Zaret BL: Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial. J Am Coll Cardiol. 1989 Apr. PMID: 2494246

Kayden DS, Mattera JA, Zaret BL, Wackers FJ: Demonstration of reperfusion after thrombolysis with technetium-99m isonitrile myocardial imaging. J Nucl Med. 1988 Nov. PMID: 2972815

Bowman LK, Lee FA, Jaffe CC, Mattera J, Wackers FJ, Zaret BL: Peak filling rate normalized to mitral stroke volume: a new Doppler echocardiographic filling index validated by radionuclide angiographic techniques. J Am Coll Cardiol. 1988 Oct. PMID: 3417992

Barrett EJ, Schwartz RG, Young LH, Jacob R, Zaret BL: Effect of chronic diabetes on myocardial fuel metabolism and insulin sensitivity. Diabetes. 1988 Jul. PMID: 3290011

Breisblatt WM, Vita NA, Armuchastegui M, Cohen LS, Zaret BL: Usefulness of serial radionuclide monitoring during graded nitroglycerin infusion for unstable angina pectoris for determining left ventricular function and individualized therapeutic dose. Am J Cardiol. 1988 Apr 1. PMID: 3128097

Brill DA, Deckelbaum LI, Remetz MS, Soufer R, Elefteriades JA, Zaret BL: Recovery of severe ischemic ventricular dysfunction after coronary artery bypass grafting. Am J Cardiol. 1988 Mar 1. PMID: 3257840

Bowman LK, Cleman MW, Cabin HS, Zaret BL, Jaffe CC: Dynamics of early and late left ventricular filling determined by Doppler two-dimensional echocardiography during percutaneous transluminal coronary angioplasty. Am J Cardiol. 1988 Mar 1. PMID: 2964191

Kayden DS, Wackers FJ, Zaret BL: The role of nuclear cardiology in assessment of acute myocardial infarction. Cardiol Clin. 1988 Feb. PMID: 3048676

Schulman DS, Biondi JW, Matthay RA, Barash PG, Zaret BL, Soufer R: Effect of positive end-expiratory pressure on right ventricular performance. Importance of baseline right ventricular function. Am J Med. 1988 Jan. PMID: 3276186

Zito RA, Cassell I, Cunningham M, Gradman AH, Ross AM, Zaret BL: High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences. Yale J Biol Med. 1980 May-Jun. PMID: 6250292

Johnstone DE, Wackers FJ, Berger HJ, Hoffer PB, Kelley MJ, Gottschalk A, Zaret BL: Effect of patient positioning on left lateral thallium-201 myocardial images. J Nucl Med. 1979 Mar. PMID: 24180034