Albert J. Sinusas, MD

Chief of Nuclear Cardiology
Professor of Diagnostic Radiology and Internal Medicine
Director of Animal Research Laboratories—Section of Cardiovascular Medicine, Yale University

Specialty: Nuclear Medicine/Nuclear Cardiology

albert.sinusas@yale.edu Phone: 203-785-4915 Fax: 204-737-1026 Yale University School of Medicine P.O. Box 208042 (CB-5029) New Haven, CT 06520-8042

Clinical Interests: Nuclear Cardiology/Cardiac MR/3D echocardiography. Post-infarction remodeling.

Research Interests: My research is directed at development of noninvasive imaging approaches for the assessment of myocardial viability, angiogenesis, and post-infarction remodeling. I have been employing the 3-D modalities of single photon emission computed tomography (SPECT), echocardiography and magnetic resonance (MR) imaging for assessment of regional myocardial perfusion, function and metabolism, in an animal physiology laboratory, employing large and small animal models of myocardial infarction, "hibernation", and "stunning". My laboratory is currently focused on targeted molecular imaging, developing non-invasive nuclear imaging strategies for identifying the hypoxic stimulus for angiogenesis, and targeted imaging of selected integrins previously established to modulate the angiogenic process, and evaluation of the role of matrix metalloproteinases on post-infarction remodeling. The investigation of these biological processes involves, in vitro cellular and whole heart preparations, as well as ex vivo and in vivo imaging in both small and large animal models, using dedicated high-resolution and real-time 3D ultrasound imaging system, a hybrid microSPECT-CT imaging system, and large animal SPECT.

Board Certifications: Nuclear Cardiology, 1997
                                   Cardiovascular Diseases, 1989
                                   Internal Medicine, 1987

Education: MD, University of Vermont, College of Medicine, 1983
                   BS, Cum Laude Biology, Rensselaer Polytechnic Institute, 1979

Residency: Medicine - University of Oklahoma , Health Science Ctr. 1984-1986

Fellowship: Cardiology - University of Virginia , Health Science Ctr. 1986-1989

Internships: Medicine - University of Oklahoma , Health Science Ctr. 1983-1984

Honors / Awards: Best Doctors in America 2001-2002
Top Doctors for Women, Cardiovascular Medicine, Connecticut Magazine 5/2002
Fellow, American College of Cardiology (FACC)
Fellow, American Heart Association (FAHA)
Fellow, American College of Physicians (FACP)

Active Grant Support:

1. NIH, NCRR Shared Instrumentation Grant 4/01/04 - 3/31/05
   1 S10 RR018039-01
   Principal Investigator: Albert J. Sinusas, M.D.
   "Dedicated Animal SPECT X-ray CT "
2. NIH - NHLBI: Radiology Study Section (RNM) 7/2001 - 6/2005
   1RO1 HL65662-01A1
   Principal Investigator: Albert J. Sinusas, M.D.
   "Non-invasive methods for imaging myocardial angiogenesis"
3. NIH - NHLBI: Radiology Study Section (ZRG1 RNM) 7/2000 - 6/2005
   5RO1 244803-01A3
   Principal Investigator: James Duncan, Ph.D.;
   Co-investigator: Albert J. Sinusas, M.D.
   "Dynamic Analysis of LV Deformation from 4D Images"
4. NIH - NHLBI: 6/2001 - 7/2006
   P01 HL70295-01
   Principal Investigator: Jordon Pober, M.D., Ph.D.
   "Chronic DTH and IFN-g in human graft arteriosclerosis"
   Principal Investigator (Project 3): Jeffrey Bender, M.D.;
   Co-Investigator: Albert J. Sinusas, M.D.
   "Project 3, Imaging DTH, IFN-gamma Response and GA in Human Arteries"
5. NIH, NCRR Shared Instrumentation Grant 4/2003 - 3/2004
   1 S10 RR16732-01
   Principal Investigator: Albert J. Sinusas, M.D.
   "Ultrasound Imaging System", For purchase of Philips Sonos7500
6. NIH - NIBIB 9/2003 - 8/2005
   1R21 EB001774-01
   Principal Investigator: YiHwa Liu, Ph.D. ;
   Co-Investigator: Albert J. Sinusas, M.D.
   "Small Animal imaging and hotspot quantification methods"
7. AHA, Heritage Affiliate Grant-in-Aid 7/2001 - 6/2005
   Principal Investigator: Purushothaman, Kailasnath PhD
   Investigator: Albert J. Sinusas, M.D.
   "Modeling the Effect of Pharmacological Stress on the Myocardial Perfusion and Tracer Patterns: Experimental Validation"
8. AHA SDG 7/2004 - 6/2008
   Principal Investigator: Mehran M. Sadeghi, M.D.
   Co-Investigator: Albert J. Sinusas, M.D.
   “Imaging a v b 3 integrin in injured arteries”
9. Hong Kong Research Grants Council 9/2003 - 8/2006
   HKUST6151/03E
   Principal Investigator: Pengcheng Shi, Ph.D. ( Hong Kong University of Science and Technology)
   Co-Investigator: Albert J. Sinusas, M.D.
   "Robust estimation of myocardial kinematics and material properties"